Article

Human CCR4-NOT globally regulates gene expression and is a novel silencer of retrotransposon activation

2024-09-10

Abstract excerpt

CCR4-NOT regulates multiple steps in gene regulation and has been well studied in budding yeast, but much less is known about the human complex. Auxin-induced degradation was used to rapidly deplete the scaffold subunit CNOT1, and CNOT4, to characterize the functions of human CCR4-NOT in gene regulation. Depleting CNOT1 increased RNA levels and caused a widespread decrease in RNA decay. In contrast, CNOT4 depletio...

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Literature Corpus work: 8266d843-cc59-5153-8b56-031a182a56b2
DOI: 10.1101/2024.09.10.612038

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