Article

Interplay between Two Paralogous Human Silencing Hub (HuSH) Complexes in Regulating LINE-1 Element Silencing

2024-01-31

Abstract excerpt

<title>Abstract</title> <p>The Human Silencing Hub (HuSH) complex is composed of TASOR, MPP8, and PPHLN1 subunits and serves as a conserved protein complex responsible for silencing transposable elements in vertebrate animals. Despite its importance, the regulatory mechanisms and recruitment dynamics governing this complex remain poorly understood. In this study, we have identified a second HuSH complex, termed H...

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Literature Corpus work: ef598db6-ab90-5435-ad6d-da85852d2999
DOI: 10.21203/rs.3.rs-3868115/v1

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