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Human CCR4-NOT suppresses pervasive transcription and retrotransposable elements

2026-01-17

Abstract excerpt

CCR4-NOT regulates multiple steps in gene regulation and has been well studied in budding yeast. Although primarily cytoplasmic, where it plays an essential role in mRNA degradation, the human complex has poorly characterized nuclear functions. Here, we used auxin-induced degradation to rapidly deplete the scaffold subunit CNOT1 and the E3 ligase CNOT4, and characterized the transcriptional functions of the human...

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Literature Corpus work
d8d0d846-9b90-5013-a56d-599ae4203d73
DOI
10.64898/2026.01.16.699749
Open publication

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Human CCR4-NOT suppresses pervasive transcription and retrotransposable elementsDOI 10.64898/2026.01.16.699749
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