Back to search

Article

PRC1.6 localizes on chromatin with the human silencing hub (HUSH) complex for promoter-specific silencing

2024-07-12

Abstract excerpt

<h4>ABSTRACT</h4> An obligate step in the life cycle of HIV-1 and other retroviruses is the establishment of the provirus in target cell chromosomes. Transcriptional regulation of proviruses is complex, and understanding the mechanisms underlying this regulation has ramifications for fundamental biology, human health, and gene therapy implementation. The three core components of the Human Silencing Hub (HUSH) com...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
86d821f0-2954-5f36-afb4-7bf1d822d3de
DOI
10.1101/2024.07.12.603173
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
PRC1.6 localizes on chromatin with the human silencing hub (HUSH) complex for promoter-specific silencingDOI 10.1101/2024.07.12.603173
TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon controlSemantic proximity
Interplay between Two Paralogous Human Silencing Hub (HuSH) Complexes in Regulating LINE-1 Element SilencingSemantic proximity
TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIVSemantic proximity
Interplay between Two Paralogous Human Silencing Hub (HuSH) Complexes in Regulating LINE-1 Element SilencingSemantic proximity
POLE3 is a repressor of unintegrated HIV-1 DNA required for efficient virus integration and escape from innate immune sensingSemantic proximity
Intrinsic immunity against HAdV is achieved by a novel epigenetic silencing complexSemantic proximity
The HUSH epigenetic repressor complex silences PML nuclear bodies-associated HSV-1 quiescent genomesSemantic proximity
The HUSH-SETDB1-MORC2 epigenetic repressor complex restricts herpesvirus infection in association with PML nuclear bodiesSemantic proximity
The HUSH epigenetic repressor complex silences PML nuclear body-associated HSV-1 quiescent genomesSemantic proximity
Human cytomegalovirus regulates host DNA repair machinery for viral genome integritySemantic proximity
Genome-wide CRISPR screenings identified SMCHD1 as a host-restricting factor for AAV transductionSemantic proximity
Human Cytomegalovirus UL138 Interaction with USP1 Activates STAT1 in infectionSemantic proximity
Select a neighboring publication to make it the new centre.