Back to search

Article

The HUSH epigenetic repressor complex silences PML nuclear bodies-associated HSV-1 quiescent genomes

2024-06-18

Abstract excerpt

Herpes simplex virus 1 (HSV-1) latently infected neurons show multiple patterns in the distribution of the viral genomes within the nucleus, at least in mouse models. One of the major patterns is characterized by the presence of quiescent HSV-1 genomes trapped in promyelocytic leukemia nuclear bodies (PML NBs) to form viral DNA-containing PML-NBs (vDCP NBs). Using a cellular model reproducing the formation of vDCP...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
765927ef-2a78-5a39-89d6-63ac4675f3ba
DOI
10.1101/2024.06.18.599571
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The HUSH epigenetic repressor complex silences PML nuclear bodies-associated HSV-1 quiescent genomesDOI 10.1101/2024.06.18.599571
The HUSH epigenetic repressor complex silences PML nuclear body-associated HSV-1 quiescent genomesSemantic proximity
The HUSH-SETDB1-MORC2 epigenetic repressor complex restricts herpesvirus infection in association with PML nuclear bodiesSemantic proximity
Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone AxisSemantic proximity
Role of ND10 nuclear bodies in the chromatin repression of HSV-1Semantic proximity
The CoREST/REST Repressor Is both Necessary and Inimical for Expression of Herpes Simplex Virus GenesSemantic proximity
Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcriptionSemantic proximity
Single-genome analysis reveals heterogeneous association of the Herpes Simplex Virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblastsSemantic proximity
Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcriptionSemantic proximity
Mechanisms of HSV gene regulation during latency and reactivationSemantic proximity
The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infectionSemantic proximity
Single-genome analysis reveals a heterogeneous association of the herpes simplex virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblastsSemantic proximity
Speckles and paraspeckles coordinate to regulate HSV-1 genes transcriptionSemantic proximity
Select a neighboring publication to make it the new centre.