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YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity

31 Jan 2022

Abstract excerpt

Abstract Background The recent discovery of the role of m6A methylation in the regulation of HIV-1 replication unveiled a novel layer of regulation for HIV gene expression. This epitranscriptomic modification of HIV-1 RNAs is under the dynamic control of specific writers and erasers. In addition, cytoplasmic readers of the m6A mark are recruited to the modified viral RNAs and regulate HIV-1 replication. Yet,...

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PMID: 35101069
DOI: 10.1186/s12977-022-00589-1

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