Article

Bacterial type 1A topoisomerases maintain the stability of the genome by preventing and dealing with R-loop-and nucleotide excision repair-dependent topological stress

2021-07-11

Abstract excerpt

<h4>ABSTRACT</h4> E. coli type 1A topoisomerases (topos), topo I ( topA ) and topo III ( topB ) have both relaxation and decatenation activities. B. subtilis and E. coli topA topB null cells can survive owing to DNA amplifications allowing overproduction of topo IV, the main cellular decatenase that can also relax supercoiling. We show that overproducing human topo IB, a relaxase but not a decatenase, can sub...

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Literature Corpus work: d3d96bbf-f768-568f-8577-2829be949ab9
DOI: 10.1101/2021.07.10.451908

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