Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Topological constraints impair RNA polymerase II transcription and causes instability of plasmid-borne convergent genes.

Nucleic acids research - 1 Feb 2012

García-Rubio María L, Aguilera Andrés

Abstract excerpt

Despite the theoretical bases for the association of topoisomerases and supercoiling changes with transcription and replication, our knowledge of the impact of topological constraints on transcription and replication is incomplete. Although mutation of topoisomerases affects expression and stability of the rDNA region it is not clear whether the same is the case for RNAPII transcription and genome integrity in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Superhelical
Share to DNA Topoisomerases, Type I
Share to DNA Topoisomerases, Type II

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Plasmids

Share to Recombination, Genetic

Share to RNA Polymerase II

Share to Saccharomyces cerevisiae Proteins

Share to Terminator Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 21998294
DOI: 10.1093/nar/gkr840
PMCID: PMC3273821

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Topological constraints impair RNA polymerase II transcription and causes instability of plasmid-borne convergent genes.PMID 21998294Read ↗

DNA supercoiling and transcription: topological coupling of promoters.Semantic proximity Read ↗

Distinguishing the roles of Topoisomerases I and II in relief of transcription-induced torsional stress in yeast rRNA genes.Semantic proximity Read ↗

Negative supercoil at gene boundaries modulates gene topology.Semantic proximity Read ↗

Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription.Semantic proximity Read ↗

Control of RNA polymerase II promoter-proximal pausing by DNA supercoilingSemantic proximity Read ↗

Genome-wide DNA supercoiling arises from transcription and SMC activity and mediates transcriptional negative feedbackSemantic proximity Read ↗

High Throughput Analyses of Budding Yeast ARSs Reveal New DNA Elements Capable of Conferring Centromere-Independent Plasmid Propagation.Semantic proximity Read ↗

Fork-barrier-independent roles of topoisomerase I in the ribosomal DNA.Semantic proximity Read ↗

Topoisomerase II is required for the production of long Pol II gene transcripts in yeast.Semantic proximity Read ↗

Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements.Semantic proximity Read ↗

Transcription-coupled hypernegative supercoiling of plasmid DNA by T7 RNA polymerase in Escherichia coli topoisomerase I-deficient strains.Semantic proximity Read ↗

DNA-Stimulated Liquid-Liquid phase separation by eukaryotic topoisomerase ii modulates catalytic functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.