Article

Integrative Systems Genomics and Pharmacology Define Shared Immune–Vascular Programs and Prioritize an Experimentally Testable Candidate Linking Sleep Loss to Human Atherosclerosis

2026-08-29

Abstract excerpt

Background: Sleep loss is epidemiologically linked to atherosclerotic cardiovascular disease, yet shared-transcriptome studies typically intersect differentially expressed gene lists and treat the overlap as a shared response, assuming rather than testing directional agreement. Methods: Controlled human sleep restriction (GSE39445; 438 whole-blood samples from 26 participants) and paired carotid plaque versus pati...

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Literature Corpus work: ba4bdbd1-71bb-54bf-9727-1313d704ebc2
DOI: 10.3390/biomedicines14091947

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Integrative Systems Genomics and Pharmacology Define Shared Immune–Vascular Programs and Prioritize an Experimentally Testable Candidate Linking Sleep Loss to Human AtherosclerosisDOI 10.3390/biomedicines14091947Read

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