Article

Cross-Cohort Optimal Transport Maps Macrophage Plasticity and Competing Routes to Inflammation and Fibrosis in Human Atherosclerotic Plaques

2026-05-19

Abstract excerpt

Single-cell transcriptomics has revealed extensive macrophage heterogeneity in atherosclerotic plaques, but how macrophages move between states, and whether transition mechanisms depend on cellular origin, remain unclear. Here we develop a computational frame-work that reconstructs directed cell-state transition networks from cross-sectional single-cell RNA-sequencing data by combining optimal transport with RNA v...

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Literature Corpus work: caf01bff-81c2-5dd8-8ab8-eebc086de2f2
DOI: 10.64898/2026.05.15.725379

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