A macrophage gene-regulatory network linked to clinical severity of coronary artery disease : The STARNET and NGS-PREDICT primary blood macrophage studies.

doi:10.1007/s00395-025-01105-0

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A macrophage gene-regulatory network linked to clinical severity of coronary artery disease : The STARNET and NGS-PREDICT primary blood macrophage studies.

Basic research in cardiology - 1 Aug 2025

Ma Lijiang, Tamis-Holland Jacqueline E, Mocci Giuseppe, Wolhuter Kathryn, Bryce Nicole S, Sajja Swathy, Amadori Letizia, Pradhan Payal, Chong Peik Sean, Sukhavasi Katyayani, Cheng Haoxiang, Li Ling, Pang Shichao, Schadt Eric E, Schunkert Heribert, von Scheidt Moritz, Ruusalepp Arno, Moreno Pedro R, Hao Ke, Giannarelli Chiara, Miller Clint L, Kovacic Jason C, Björkegren Johan L M

Abstract excerpt

Coronary artery disease (CAD) is a major cause of global morbidity and mortality. Macrophages play a central role in orchestrating this disease process. In 2016, we initiated the STARNET primary blood macrophage study, followed by the multi-ethnic NGS-PREDICT primary blood macrophage study in 2018. We applied integrative systems genetics analysis to explore and validate the role of macrophage gene regulatory...

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PMID: 40590916
DOI: 10.1007/s00395-025-01105-0

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