Article
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis.
Nature - 1 Jul 2026
Gerhardt Teresa, Jacob Walter, Gaebel Lena, Heiser Merlin, Wolfram Christopher, Huynh Pacific, Nakao Tetsushi, Gindri Dos Santos Bernardo, Toh Pamela, Douglas Aaron, Brisnovali Niki F, Radkevich Emir, Uddin Md Mesbah, Yates Abi G, Khamhoung Annie, Yatim Nader, Gianeselli Matteo, Kiss Máté G, Goswami Sukanya, Nelson Daniella, Chen Rachel, D'Souza Darwin, Chen Zhihong, Kim-Schulze Seunghee, Fidler Trevor, Ezzat Daniel, Khurshid Shaan, Bick Alexander G, Natarajan Pradeep, Ellinor Patrick T, Rajbhandari Abha K, Merad Miriam, Swirski Filip K, Cohen Oren, Goedeke Leigh, Honigberg Michael C, McAlpine Cameron S
Abstract excerpt
Clonal haematopoiesis (CH) activates inflammation and increases the risk of atherosclerosis1,2. Whether lifestyle alters CH clone expansion or the phenotypic programming of CH mutant cells, thereby affecting atherosclerosis, is unknown. Here, in humans and mice and across mutations in Jak2, Tet2, Trp53 and Dnmt3a, we demonstrate mutation-dependent responses to sleep and exercise in CH and show that mutant cells...
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