Cross-species single-cell RNA sequencing reveals divergent phenotypes and activation states of adaptive immunity in human carotid and experimental murine atherosclerosis.

doi:10.1093/cvr/cvae154

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Cross-species single-cell RNA sequencing reveals divergent phenotypes and activation states of adaptive immunity in human carotid and experimental murine atherosclerosis.

Cardiovascular research - 25 Nov 2024

Horstmann Hauke, Michel Nathaly Anto, Sheng Xia, Hansen Sophie, Lindau Alexandra, Pfeil Katharina, Fernández Marbely C, Marchini Timoteo, Winkels Holger, Mitre Lucia Sol, Abogunloko Tijani, Li Xiaowei, Mwinyella Timothy Bon-Nawul, Gissler Mark Colin, Bugger Heiko, Heidt Timo, Buscher Konrad, Hilgendorf Ingo, Stachon Peter, Piepenburg Sven, Verheyen Nicolas, Rathner Thomas, Gerhardt Teresa, Siegel Patrick Malcolm, Oswald Wolfgang Kurt, Cohnert Tina, Zernecke Alma, Madl Josef, Kohl Peter, Foks Amanda C, von Zur Muehlen Constantin, Westermann Dirk, Zirlik Andreas, Wolf Dennis

Abstract excerpt

AIMS: The distinct functions of immune cells in atherosclerosis have been mostly defined by pre-clinical mouse studies. Contrastingly, the immune cell composition of human atherosclerotic plaques and their contribution to disease progression are only poorly understood. It remains uncertain whether genetic animal models allow for valuable translational approaches. METHODS AND RESULTS: Single-cell RNA-sequencing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptive Immunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carotid Arteries

Share to Carotid Artery Diseases

Share to Lymphocyte Activation

Share to Mice, Knockout, ApoE

Share to Plaque, Atherosclerotic

Share to RNA-Seq

Share to Single-Cell Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 39041203
DOI: 10.1093/cvr/cvae154
PMCID: PMC11587564

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cross-species single-cell RNA sequencing reveals divergent phenotypes and activation states of adaptive immunity in human carotid and experimental murine atherosclerosis.PMID 39041203Read ↗

Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry.Semantic proximity Read ↗

Integrated scRNA-seq analysis identifies conserved transcriptomic features of mononuclear phagocytes in mouse and human atherosclerosisSemantic proximity Read ↗

Heterogeneity of immune cells in human atherosclerosis revealed by scRNA-Seq.Semantic proximity Read ↗

Immune Profiling of Atherosclerotic Plaques Identifies Innate and Adaptive Dysregulations Associated with Ischemic Cerebrovascular EventsSemantic proximity Read ↗

High-Dimensional Single-Cell Multimodal Landscape of Human Carotid AtherosclerosisSemantic proximity Read ↗

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics.Semantic proximity Read ↗

Molecular and spatiotemporal characterization of cells in murine atherosclerotic plaquesSemantic proximity Read ↗

Integrated single-cell atlas of human atherosclerotic plaquesSemantic proximity Read ↗

Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.Semantic proximity Read ↗

Encompassing view of spatial and single-cell RNA-seq renews the role of the microvasculature in human atherosclerosisSemantic proximity Read ↗

Autoimmune-like CD8⁺ T Cell Responses Drive Atherosclerotic Plaque Instability and Predict Cardiovascular EventsSemantic proximity Read ↗

Heterogeneity of macrophages in atherosclerosis revealed by single-cell RNA sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.