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Programmatic Adaptive Failure in Myeloid Cells: A Novel Mechanism Linking Frailty to Accelerated Epigenetic Aging

2026-03-16

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<title>Abstract</title> <p> <bold>Background</bold> Frailty is a hallmark of accelerated biological aging, yet the causal pathways and cellular-molecular mechanisms driving the vicious cycle of "frailty-inflammation-aging" remain unclear. <bold>Methods</bold> This study employed a multi-level integrative analysis: 1) validation of associations and inflammatory mediation based on the NHANES cohort; 2) establis...

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Literature Corpus work
6747f28e-6004-559c-9ef7-fb201cba696f
DOI
10.21203/rs.3.rs-8715723/v1
Open publication

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Programmatic Adaptive Failure in Myeloid Cells: A Novel Mechanism Linking Frailty to Accelerated Epigenetic AgingDOI 10.21203/rs.3.rs-8715723/v1
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