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Article

Epigenetic alterations in obstructive sleep Apnea: a pooled analysis of DNA methylation profiles in humans and animal models

19 Nov 2025

Abstract excerpt

BACKGROUND: Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder characterized by recurrent episodes of intermittent hypoxia (IH) and sleep fragmentation. OSA is strongly associated with cardiometabolic morbidities, many of which correlate with the severity of IH. While the genetic basis of OSA remains unclear, epigenetic modifications, particularly DNA methylation, have emerged as key contributors...

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PMID: 41257924
DOI: 10.1186/s13148-025-02009-5

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