Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aorta macrophage inflammatory and epigenetic changes in a murine model of obstructive sleep apnea: Potential role of CD36.

Scientific reports - 27 Feb 2017

Cortese Rene, Gileles-Hillel Alex, Khalyfa Abdelnaby, Almendros Isaac, Akbarpour Mahzad, Khalyfa Ahamed A, Qiao Zhuanghong, Garcia Tzintzuni, Andrade Jorge, Gozal David

Abstract excerpt

Obstructive sleep apnea (OSA) affects 8-10% of the population, is characterized by chronic intermittent hypoxia (CIH), and causally associates with cardiovascular morbidities. In CIH-exposed mice, closely mimicking the chronicity of human OSA, increased accumulation and proliferation of pro-inflammatory metabolic M1-like macrophages highly expressing CD36, emerged in aorta. Transcriptomic and MeDIP-seq approaches...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta
Share to CD36 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelium

Share to Epigenesis, Genetic

Share to Gene Regulatory Networks

Share to Immunophenotyping

Share to Macrophages

Share to Sleep Apnea, Obstructive

Source

Open in PubMed Open full text

Identifiers

PMID: 28240319
DOI: 10.1038/srep43648
PMCID: PMC5327416

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aorta macrophage inflammatory and epigenetic changes in a murine model of obstructive sleep apnea: Potential role of CD36.PMID 28240319Read ↗

Epigenetic alterations in obstructive sleep Apnea: a pooled analysis of DNA methylation profiles in humans and animal modelsSemantic proximity Read ↗

Intermittent Hypoxia Mimicking Sleep Apnea Induces Systemic and Tissue Specific Epigenetic Changes and p16-Mediated Cellular Senescence Underlying Vascular DysfunctionSemantic proximity Read ↗

Single-cell transcriptome analysis reveals cellular heterogeneity in the ascending aortas of normal and high-fat diet-fed miceSemantic proximity Read ↗

Murine models of sleep apnea: functional implications of altered macrophage polarity and epigenetic modifications in adipose and vascular tissuesSemantic proximity Read ↗

Association between proteomics and obstructive sleep apnea phenotypes in a community-based cohort of women.Semantic proximity Read ↗

Chronic Intermittent Hypoxia Participates in the Pathogenesis of Atherosclerosis and Perturbs the Formation of Intestinal MicrobiotaSemantic proximity Read ↗

Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary diseaseSemantic proximity Read ↗

Atherogenesis: hyperhomocysteinemia interactions with LDL, macrophage function, paraoxonase 1, and exerciseSemantic proximity Read ↗

Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis.Semantic proximity Read ↗

Hidden features: CD36/SR-B2, a master regulator of macrophage phenotype/function through metabolism.Semantic proximity Read ↗

Inflammation, physical activity, and chronic disease: An evolutionary perspectiveSemantic proximity Read ↗

Trimethylamine-N-oxide affects cell type-specific pathways and networks in mouse aorta to promote atherosclerotic plaque vulnerabilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.