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Single-Cell Transcriptomic and Co-Expression Network Analysis Identifies a Conserved Macrophage Program Associated with Osteoarthritis and Coronary Heart Disease Comorbidity

2026-06-22

Abstract excerpt

<title>Abstract</title> <p>Background Osteoarthritis (OA) and coronary heart disease (CHD) exhibit high rates of clinical co-occurrence, yet the shared cellular and molecular mechanisms underlying this comorbidity remain poorly defined. While systemic inflammation is implicated, the specific cell types and transcriptional programs that bridge these distinct tissue pathologies have not been identified at single-c...

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Literature Corpus work
a2b8c77b-5489-54a6-b33d-b3c3c61361b8
DOI
10.21203/rs.3.rs-9582946/v1
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Single-Cell Transcriptomic and Co-Expression Network Analysis Identifies a Conserved Macrophage Program Associated with Osteoarthritis and Coronary Heart Disease ComorbidityDOI 10.21203/rs.3.rs-9582946/v1
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