Article
Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) study.
PLoS genetics - 1 Dec 2009
Hägg Sara, Skogsberg Josefin, Lundström Jesper, Noori Peri, Nilsson Roland, Zhong Hua, Maleki Shohreh, Shang Ming-Mei, Brinne Björn, Bradshaw Maria, Bajic Vladimir B, Samnegård Ann, Silveira Angela, Kaplan Lee M, Gigante Bruna, Leander Karin, de Faire Ulf, Rosfors Stefan, Lockowandt Ulf, Liska Jan, Konrad Peter, Takolander Rabbe, Franco-Cereceda Anders, Schadt Eric E, Ivert Torbjörn, Hamsten Anders, Tegnér Jesper, Björkegren Johan
Abstract excerpt
Environmental exposures filtered through the genetic make-up of each individual alter the transcriptional repertoire in organs central to metabolic homeostasis, thereby affecting arterial lipid accumulation, inflammation, and the development of coronary artery disease (CAD). The primary aim of the Stockholm Atherosclerosis Gene Expression (STAGE) study was to determine whether there are functionally associated...
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