Article

Immune Profiling of Atherosclerotic Plaques Identifies Innate and Adaptive Dysregulations Associated with Ischemic Cerebrovascular Events

2019-08-02

Abstract excerpt

<h4>SUMMARY</h4> Atherosclerosis is driven by multifaceted contributions of the immune system within the circulation and at vascular focal sites. Yet the specific immune dysregulations within the atherosclerotic lesions that lead to clinical cerebro- and cardiovascular complications (i.e. ischemic stroke and myocardial infarction) are poorly understood. Here, using single-cell mass cytometry with Cellular Indexin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 861cb73f-a775-50d5-8793-c0ce3021d7c3
DOI: 10.1101/721688

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immune Profiling of Atherosclerotic Plaques Identifies Innate and Adaptive Dysregulations Associated with Ischemic Cerebrovascular EventsDOI 10.1101/721688Read

High-Dimensional Single-Cell Multimodal Landscape of Human Carotid AtherosclerosisSemantic proximity Read

Autoimmune-like CD8⁺ T Cell Responses Drive Atherosclerotic Plaque Instability and Predict Cardiovascular EventsSemantic proximity Read

Single‐cell and bulk characterisation of the distinct immune landscape and possible regulatory mechanisms in coronary plaques vulnerabilitySemantic proximity Read

T Cells in Atherosclerosis: Key Players in the Pathogenesis of Vascular DiseaseSemantic proximity Read

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics.Semantic proximity Read

Single-Cell RNA Sequencing Reveals an Immune Landscape of CD4+ T Cells in Coronary Culprit Plaques With Acute Coronary Syndrome in Humans-Brief Report.Semantic proximity Read

Heterogeneity of immune cells in human atherosclerosis revealed by scRNA-Seq.Semantic proximity Read

A Review of Macrophage Diversity and Immune Checkpoint Regulation in Atherosclerosis: Insights from Single-Cell TranscriptomesSemantic proximity Read

Integrated single-cell atlas of human atherosclerotic plaquesSemantic proximity Read

Cross-species single-cell RNA sequencing reveals divergent phenotypes and activation states of adaptive immunity in human carotid and experimental murine atherosclerosis.Semantic proximity Read

Identification of potential therapeutic targets for atherosclerosis by analysing the gene signature related to different immune cells and immune regulators in atheromatous plaquesSemantic proximity Read

Molecular and spatiotemporal characterization of cells in murine atherosclerotic plaquesSemantic proximity Read