Article

Endocytosis is regulated through the pH-dependent phosphorylation of Rab GTPases by Parkinson’s kinase LRRK2

2023-02-15

Abstract excerpt

<h4>ABSTRACT</h4> While it has been known for decades that luminal acidification is required for normal traffic along the endocytic pathway, the precise underlying mechanism(s) remain unknown. We found that dissipation of the endomembrane pH gradient resulted in acute formation of large Rab5- or Rab7-positive vacuoles. Vacuole formation was associated with and required hyperactivation of the Rabs, which was attri...

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Literature Corpus work: eeaed77b-09a0-5efa-bc63-978918d5d8f4
DOI: 10.1101/2023.02.15.528749

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