Article

A neuronal CRISPRi screen identifies PQLC2 as a lysosomal pH regulator controlling tau homeostasis

2026-08-28

Abstract excerpt

Lysosomes make key contributions to the maintenance of cellular proteostasis, and their functional compromise has been linked to aging and neurodegenerative disease. A defining characteristic of lysosomes is their relative acidity compared to other subcellular compartments, a quality that enables the efficient breakdown of macromolecules. Evidence suggests that neuronal lysosomal pH becomes dysregulated with aging...

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Literature Corpus work: 914a60be-ebea-50b7-8259-378619672358
DOI: 10.64898/2026.08.25.747102

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