Article

Single-Cell and Spatial Multi-omics Reveal Interferon Signaling in the Pathogenesis of Perianal Fistulizing Crohn’s Disease

2024-11-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background & Aims</h4> Perianal fistulizing Crohn’s disease (PCD) is a common and debilitating complication with elusive pathophysiology. We examined mucosal cells from patients with PCD and related conditions using a multi-omics approach. <h4>Methods</h4> We recruited patients with PCD (n = 24), CD without perianal disease (NPCD, n = 10), and idiopathic perianal fistulas (IPF, n = 29). Bi...

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Literature Corpus work: 14bc120f-badd-5658-a650-58b2a6c92519
DOI: 10.1101/2024.11.08.620717

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