Article

Single-Cell RNA Sequencing of Terminal Ileal Biopsies Identifies Signatures of Crohn’s Disease Pathogenesis

2023-09-08

Abstract excerpt

<h4>Summary</h4> Crohn’s disease (CD) is a chronic inflammatory bowel disease exhibiting substantial heterogeneity in clinical presentation and response to therapy. To explore its molecular basis, we developed IBDverse, the largest single-cell RNA sequencing (scRNA-seq) dataset of terminal ileal biopsies, profiling over 1.1 million cells from 111 CD patients and 232 healthy controls. This resource integrates disc...

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Literature Corpus work: 527b5d4f-ad2f-5a89-ba45-d69c28dba757
DOI: 10.1101/2023.09.06.23295056

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