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TL1A-activated T cells remodel the rectal mucosa in Crohn’s disease patients with perianal fistulizing disease

2025-06-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Perianal fistulizing disease (PFD) is a complication that affects about 20% of Crohn’s disease (CD) patients whose etiology remains unknown. <h4>Objectives</h4> To identify predisposing events driving fistula formation. <h4>Design</h4> Rectal biopsies from CD patients with or without PFD (CD+PFD and CD, respectively; n=31) were collected and subjected to single-cell RNA se...

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Literature Corpus work
90b168f2-9bf4-5d2a-9a26-c0c67856347c
DOI
10.1101/2025.06.26.657455
Open publication

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TL1A-activated T cells remodel the rectal mucosa in Crohn’s disease patients with perianal fistulizing diseaseDOI 10.1101/2025.06.26.657455
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