Article

Neutrophil-fibroblast crosstalk drives immunofibrosis in Crohn’s disease through IFNα pathway

2023-09-11

Abstract excerpt

This study investigated the interaction between neutrophils and intestinal fibroblasts in Crohn’s disease (CD) immunofibrosis. Peripheral neutrophils, enriched-neutrophil extracellular traps (eNETs), serum, primary intestinal fibroblasts (PIFs) and intestinal biopsies were studied. Neutrophils’ RNA-sequencing, multi-cytokine profiling and cell-based functional assays at mRNA/protein level were performed. Compared...

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Literature Corpus work: 1eb9223e-9ac9-52ea-96e9-769a382c6840
DOI: 10.1101/2023.09.08.23295281

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