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Article

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome

1 May 2023

Abstract excerpt

The Commander complex is required for endosomal recycling of diverse transmembrane cargos and is mutated in Ritscher-Schinzel syndrome. It comprises two sub-assemblies: Retriever composed of VPS35L, VPS26C, and VPS29; and the CCC complex which contains twelve subunits: COMMD1-COMMD10 and the coiled-coil domain-containing (CCDC) proteins CCDC22 and CCDC93. Combining X-ray crystallography, electron cryomicroscopy,...

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PMID: 37172566
DOI: 10.1016/j.cell.2023.04.003

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