Article

Multiomic Approach Characterises the Neuroprotective Role of Retromer in Regulating Lysosomal Health

2022-09-15

Abstract excerpt

<h4>ABSTRACT</h4> Retromer controls cellular homeostasis through regulating integral membrane protein sorting and transport and by controlling late-stage maturation of the endo-lysosomal network. Retromer dysfunction, which is linked to neurodegenerative disorders including Parkinson’s and Alzheimer’s diseases, manifests in complex cellular phenotypes, though the precise nature of this dysfunction, and its relati...

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Literature Corpus work: 65864043-0297-57c2-afc6-805ecba9fb63
DOI: 10.1101/2022.09.13.507260

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