Article

Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain

2019-10-01

Abstract excerpt

Retromer, including Vps35, Vps26, and Vps29, is a protein complex responsible for recycling proteins within the endolysosomal pathway. Although implicated in both Parkinson’s and Alzheimer’s disease, our understanding of retromer function in the adult brain remains limited, in part because Vps35 and Vps26 are essential for development. In Drosophila , we find that Vps29 is dispensable for embryogenesis but req...

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Literature Corpus work: 6caeb286-d891-510e-9d2e-c81d4318f7ea
DOI: 10.1101/788711

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