Article

Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

2023-01-26

Abstract excerpt

<h4>SUMMARY</h4> The Commander complex is required for endosomal recycling of diverse transmembrane cargos and is mutated in Ritscher-Schinzel syndrome. It comprises two subassemblies; Retriever composed of VPS35L, VPS26C and VPS29, and the CCC complex which contains ten subunits COMMD1-COMMD10 and two coiled-coil domain-containing (CCDC) proteins CCDC22 and CCDC93. Combining X-ray crystallography, electron cryom...

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Literature Corpus work: 5fba11dd-d655-57fe-b971-ac7c68059677
DOI: 10.1101/2023.01.25.525455

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