Article

Quantification of DNA methylation using methylation-sensitive restriction enzymes and multiplex digital PCR

2019-10-24

Abstract excerpt

<h4>ABSTRACT</h4> Epigenetic regulation is important in human health and disease, but the exact mechanisms remain largely enigmatic. DNA methylation represents one well-studied aspect of epigenetic regulation, but is challenging to quantify accurately. In this study, we introduce a digital approach for the absolute quantification of the amount, density and allele-specificity of DNA methylation. Combining the effi...

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Literature Corpus work: ba3131c6-d87a-5d75-b748-b47d71c0ccc5
DOI: 10.1101/816744

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