Article
Analysis and accurate quantification of CpG methylation by MALDI mass spectrometry.
Nucleic acids research - 1 May 2003
Tost Jörg, Schatz Philipp, Schuster Matthias, Berlin Kurt, Gut Ivo Glynne
Abstract excerpt
As the DNA sequence of the human genome is now nearly finished, the main task of genome research is to elucidate gene function and regulation. DNA methylation is of particular importance for gene regulation and is strongly implicated in the development of cancer. Even minor changes in the degree of methylation can have severe consequences. An accurate quantification of the methylation status at any given position...
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