Article
The implications of heterogeneous DNA methylation for the accurate quantification of methylation.
Epigenomics - 1 Aug 2010
Mikeska Thomas, Candiloro Ida L M, Dobrovic Alexander
Abstract excerpt
DNA methylation based biomarkers have considerable potential for molecular diagnostics, both as tumor specific biomarkers for the early detection or post-therapeutic monitoring of cancer as well as prognostic and predictive biomarkers for therapeutic stratification. Particularly in the former, the accurate estimation of DNA methylation is of compelling importance. However, quantification of DNA methylation has...
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