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A Summary of the Biological Processes, Disease-Associated Changes, and Clinical Applications of DNA Methylation.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Andersen Gitte Brinch, Tost Jörg

Abstract excerpt

DNA methylation at cytosines followed by guanines, CpGs, forms one of the multiple layers of epigenetic mechanisms controlling and modulating gene expression through chromatin structure. It closely interacts with histone modifications and chromatin remodeling complexes to form the local genomic and higher-order chromatin landscape. DNA methylation is essential for proper mammalian development, crucial for...

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PMID: 29224136
DOI: 10.1007/978-1-4939-7481-8_1

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