Article

Comparing methylation levels assayed in GC-rich regions with current and emerging methods

2023-09-09

Abstract excerpt

DNA methylation is an epigenetic mechanism that regulates gene expression, and for mammals typically occurs on cytosines within CpG dinucleotides. A significant challenge for methylation detection methods is accurately measuring methylation levels within GC-rich regions such as gene promoters, as inaccuracies compromise downstream biological interpretation of the data. To address this challenge, we compared methyl...

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Literature Corpus work: ec47b711-c4db-5b63-8d4e-395169973824
DOI: 10.1101/2023.09.06.556603

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