Article

Stable integrant-specific differences in bimodal HIV-1 expression patterns revealed by high-throughput analysis

2019-06-11

Abstract excerpt

HIV-1 gene expression is regulated by host and viral factors that interact with viral motifs and is influenced by proviral integration sites. Here, expression variation among integrants was followed for hundreds of individual proviral clones within polyclonal populations throughout successive rounds of virus and cultured cell replication. Initial findings in immortalized cells were validated using CD4+ cells from...

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Literature Corpus work: ba1a38c8-9953-507d-a197-69e791cbe7af
DOI: 10.1101/666941

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