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Article

Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model

25 Jul 2017

Abstract excerpt

Combination anti-retroviral therapy (cART) has drastically improved the clinical outcome of HIV-1 infection. Nonetheless, despite effective cART, HIV-1 persists indefinitely in infected individuals. Clonal expansion of HIV-1-infected cells in peripheral blood has been reported recently. cART is effective in stopping the retroviral replication cycle, but not in inhibiting clonal expansion of the infected host...

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PMID: 28761140
DOI: 10.1038/s41598-017-07307-4

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