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Article

Barcoded HIV-1 reveals viral persistence driven by clonal proliferation and distinct epigenetic patterns.

Nature communications - 14 Feb 2025

Zhang Tian-Hao, Shi Yuan, Komarova Natalia L, Wodarz Dominik, Kostelny Matthew, Gonzales Alexander, Abbaali Izra, Chen Hongying, Bresson-Tan Gabrielle, Dimapasoc Melanie, Harvey William, Oh Christopher, Carmona Camille, Seet Christopher, Du Yushen, Sun Ren, Zack Jerome A, Kim Jocelyn T

Abstract excerpt

The HIV reservoir consists of infected cells in which the HIV-1 genome persists as provirus despite effective antiretroviral therapy (ART). Studies exploring HIV cure therapies often measure intact proviral DNA levels, time to rebound after ART interruption, or ex vivo stimulation assays of latently infected cells. This study utilizes barcoded HIV to analyze the reservoir in humanized mice. Using bulk PCR and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39952916
DOI: 10.1038/s41467-025-56771-4
PMCID: PMC11829055

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