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Article

Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection

11 Jul 2014

Abstract excerpt

Antiretroviral treatment (ART) of HIV infection suppresses viral replication. Yet if ART is stopped, virus reemerges because of the persistence of infected cells. We evaluated the contribution of infected-cell proliferation and sites of proviral integration to HIV persistence. A total of 534 HIV integration sites (IS) and 63 adjacent HIV env sequences were derived from three study participants over 11.3 to 12.7...

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PMID: 25011556
DOI: 10.1126/science.1256304

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