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Article

Phenotypic characterization of single CD4+ T cells harboring genetically intact and inducible HIV genomes.

Nature communications - 27 Feb 2023

Dufour Caroline, Richard Corentin, Pardons Marion, Massanella Marta, Ackaoui Antoine, Murrell Ben, Routy Bertrand, Thomas Réjean, Routy Jean-Pierre, Fromentin Rémi, Chomont Nicolas

Abstract excerpt

The phenotype of the rare HIV-infected cells persisting during antiretroviral therapies (ART) remains elusive. We developed a single-cell approach that combines the phenotypic analysis of HIV-infected cells with near full-length sequencing of their associated proviruses to characterize the viral reservoir in 6 male individuals on suppressive ART. We show that individual cells carrying clonally expanded identical...

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Identifiers

PMID: 36849523
DOI: 10.1038/s41467-023-36772-x
PMCID: PMC9971253

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