Article
HIV Provirus Stably Reproduces Parental Latent and Induced Transcription Phenotypes Regardless of the Chromosomal Integration Site.
Journal of virology - 1 Jun 2016
Hashemi Farhad B, Barreto Kris, Bernhard Wendy, Hashemi Pargol, Lomness Adam, Sadowski Ivan
Abstract excerpt
UNLABELLED: Understanding the mechanisms of HIV proviral latency is essential for development of a means to eradicate infection and achieve a cure. We have previously described an in vitro latency model that reliably identifies HIV expression phenotypes of infected cells using a dual-fluorescence reporter virus. Our results have demonstrated that ∼50% of infected cells establish latency immediately upon...
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