Article

Ex vivo HIV DNA integration in STAT3 drives T cell persistence—A model of HIV-associated T cell lymphoma

2025-03-31

Abstract excerpt

Oncogenic retroviruses are known for their pathogenesis via insertional mutagenesis, in which the presence of a provirus and its transcriptional control elements alter the expression of a nearby or surrounding host gene. There are reports of proviral integration driving oncogenesis in people with HIV and the use of HIV-derived vectors for gene therapy has raised concern about oncogenic side effects. To study this...

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Literature Corpus work: e8de9602-c426-5972-abac-45fd2857ee84
DOI: 10.1101/2025.03.31.646272

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