Article

HIV-1 Integration Site Determines the Transcriptional Fate and Persistence of Integrated Proviruses

2025-12-26

Abstract excerpt

<h4>Summary</h4> The mechanisms by which latent HIV-1 reservoirs persist during antiretroviral therapy is incompletely understood. Here, we derive a model system to measure clonal expansion and viral latency in which populations of human memory CD4 + T cells, each bearing a single transcriptionally active HIV-1 provirus are engrafted into immunodeficient mice. Over ∼2 months in vivo , clonal expansion and the e...

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Literature Corpus work: 58dbf951-942b-5164-a780-e9486920f072
DOI: 10.64898/2025.12.26.696579

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