Article

HTLV-1 clonality in natural infection

2013-01-01

Abstract excerpt

Human T-Lymphotropic virus type 1 (HTLV-1) maintains persistent infection in the host by driving expansion of HTLV-1-infected T cells. However, the wide variation observed in clonal abundance in vivo remains unexplained. We hypothesize that the site of proviral integration in the host cell genome determines the rate of expression of HTLV-1 genes such as the viral transactivator Tax, which in turn determine the lev...

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Literature Corpus work: fb9f095c-5a77-5d82-9aa5-98e35e4d5b1c
DOI: 10.25560/14372

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