Article

Lipid-protecting disulfide bridges are the missing molecular link between ApoE4 and sporadic Alzheimer’s disease in humans

2025-01-18

Abstract excerpt

As the principal lipid transporter in the human brain, apolipoprotein E (ApoE) is tasked with the transport and protection of highly vulnerable lipids required to support and remodel neuronal membranes, in a process that is dependent on ApoE receptors. Human APOE allele variants that encode proteins differing only in the number of cysteine (Cys)-to-arginine (Arg) exchanges (ApoE2 [2 Cys], ApoE3 [1 Cys], ApoE4 [0...

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Literature Corpus work: a314166e-8a62-5543-90f4-17ab4a934c38
DOI: 10.1101/2025.01.17.633633

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