Article

Human mismatch repair system corrects errors produced during lagging strand replication more effectively

2016-03-23

Abstract excerpt

Mismatch repair (MMR) is one of the main systems maintaining fidelity of replication. Different effectiveness in correction of errors produced during replication of the leading and the lagging DNA strands was reported in yeast, but this effect is poorly studied in humans. Here, we use MMR-deficient (MSI) and MMR-proficient (MSS) cancer samples to investigate properties of the human MMR. MSI, but not MSS, cancers d...

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Literature Corpus work: 72ff2f6d-7e9d-5a52-ad0c-f973c5f2540d
DOI: 10.1101/045278

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