Suppressing APOE4-induced mortality and cellular damage by targeting VHL

Abstract excerpt

Mortality rate increases with age and can accelerate upon extrinsic or intrinsic damage to individuals. Identifying factors and mechanisms that curb population mortality rate has wide-ranging implications. Here, we show that targeting the VHL-1 (Von Hippel– Lindau) protein suppresses C. elegans mortality caused by distinct factors, including elevated reactive oxygen species, temperature, and APOE4 , the genetic...

Topics

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• Caenorhabditis elegans
• Caenorhabditis elegans Proteins
• Forkhead Transcription Factors
• Genetics, Aging, and Longevity in Model Organisms
• Longevity
• Mutation
• Reverse Transcriptase Polymerase Chain Reaction
• Transcription Factors

Identifiers and source

Literature Corpus work

b99973ba-ffa5-5192-9669-6b4faa627446

DOI

10.1101/2024.02.28.582664