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Article

FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation

9 Jan 2021

Abstract excerpt

Mitochondrial quality control (MQC) balances organelle adaptation and elimination, and mechanistic crosstalk between the underlying molecular processes affects subsequent stress outcomes. FUNDC1 (FUN14 domain containing 1) is a mammalian mitophagy receptor that responds to hypoxia-reoxygenation (HR) stress. Here, we provide evidence that FNDC-1 is the C. elegans ortholog of FUNDC1, and that its loss protects...

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PMID: 33416042
DOI: 10.1080/15548627.2021.1872885

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