Article
The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans.
PloS one - 27 Jul 2009
Zhang Yi, Shao Zhiyong, Zhai Zhiwei, Shen Chuan, Powell-Coffman Jo Anne
Abstract excerpt
During normal development or during disease, animal cells experience hypoxic (low oxygen) conditions, and the hypoxia-inducible factor (HIF) transcription factors implement most of the critical changes in gene expression that enable animals to adapt to this stress. Here, we examine the roles of HIF-1 in post-mitotic aging. We examined the effects of HIF-1 over-expression and of hif-1 loss-of-function mutations on...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Longevity
- Mutation
- Reverse Transcriptase Polymerase Chain Reaction
- Transcription Factors