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Article

The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans.

PloS one - 27 Jul 2009

Zhang Yi, Shao Zhiyong, Zhai Zhiwei, Shen Chuan, Powell-Coffman Jo Anne

Abstract excerpt

During normal development or during disease, animal cells experience hypoxic (low oxygen) conditions, and the hypoxia-inducible factor (HIF) transcription factors implement most of the critical changes in gene expression that enable animals to adapt to this stress. Here, we examine the roles of HIF-1 in post-mitotic aging. We examined the effects of HIF-1 over-expression and of hif-1 loss-of-function mutations on...

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Identifiers

PMID: 19633713
DOI: 10.1371/journal.pone.0006348
PMCID: PMC2711329

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