Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans.

PLoS biology - 1 Oct 2004

Bishop Tammie, Lau Kah Weng, Epstein Andrew C R, Kim Stuart K, Jiang Min, O'Rourke Delia, Pugh Christopher W, Gleadle Jonathan M, Taylor Martin S, Hodgkin Jonathan, Ratcliffe Peter J

Abstract excerpt

The von Hippel-Lindau (VHL) tumor suppressor functions as a ubiquitin ligase that mediates proteolytic inactivation of hydroxylated alpha subunits of hypoxia-inducible factor (HIF). Although studies of VHL-defective renal carcinoma cells suggest the existence of other VHL tumor suppressor pathways, dysregulation of the HIF transcriptional cascade has extensive effects that make it difficult to distinguish...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Extracellular Matrix

Share to Genome

Share to Ribonucleases

Share to Up-Regulation

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 15361934
DOI: 10.1371/journal.pbio.0020289
PMCID: PMC515368

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans.PMID 15361934Read ↗

The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1.Semantic proximity Read ↗

Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans.Semantic proximity Read ↗

Genetic analysis of hypoxia signaling and response in C elegans.Semantic proximity Read ↗

A VHL-1;HIF-1/SQRD1/COL-88 axis links extracellular matrix formation with longevity in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans.Semantic proximity Read ↗

Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner.Semantic proximity Read ↗

Recent advances in etiology and treatment of von Hippel-Lindau Disease (VHLD).Semantic proximity Read ↗

Crosstalk in oxygen homeostasis networks: SKN-1/NRF inhibits the HIF-1 hypoxia-inducible factor in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Systematic identification of gene activities promoting hypoxic death.Semantic proximity Read ↗

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling.Semantic proximity Read ↗

The VHL tumor suppressor and HIF: insights from genetic studies in mice.Semantic proximity Read ↗

Suppressing APOE4-induced mortality and cellular damage by targeting VHLSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.