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Article

Proteasomal Regulation of the Hypoxic Response Modulates Aging in <i>C. elegans</i>

16 Apr 2009

Abstract excerpt

Anti-Aging Several human neurodegenerative diseases, such as Alzheimer's and Huntington's, are caused by aberrant protein aggregation. These disorders typically develop after the fifth decade of life, suggesting a connection with the aging process. In a number of different species, life span can be extended by dietary restriction and reduced insulin and insulin-like growth factor–1 (IGF-1) signaling. These...

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PMID: 19372390
DOI: 10.1126/science.1173507

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